Vol. 1, Issue 3, 2010

A review of literature reports of interaction and incompatibilities of commonly used pharmaceutical excipients with different active pharmaceutical ingredients in solid dosage forms.

A review on how inulin’s unique physico-chemical properties bestow it with many useful pharmaceutical applications.

Using the data from multiple in vitro studies, a model has been conceptualized that underscores the attributes of both the HLB and the critical micellar concentration (CMC), occurring in tandem, and unable of being varied independently, as key determinants toward prediction of surfactant Pgp inhibition
activity. The algorithm that formalizes this concept provides a ‘semi-rational’ method of choosing surfactants for a specific type of cancer for maximum inhibition of MDR.

Macromolecular excipients are unique in that each (macro)molecule or polymer chain can chemically differ significantly from another. However, these differences may not be detected across different lots or different samples because the analytical methods used to characterize such samples typically can only detect the average of the different individual molecular chemical attributes.